{"id":400,"date":"2008-07-12T14:19:41","date_gmt":"2008-07-12T11:19:41","guid":{"rendered":"https:\/\/armonia-zoi.gr\/?p=400"},"modified":"2014-02-12T14:20:20","modified_gmt":"2014-02-12T12:20:20","slug":"%ce%bf-%ce%b1%ce%be%ce%bf%ce%bd%ce%b1%cf%82-%cf%84%cf%89%ce%bd-%ce%b9%ce%bd%ce%ba%cf%81%ce%b5%cf%84%ce%b9%ce%bd%cf%8e%ce%bd-%ce%ba%ce%b1%ce%b9-%ce%bf-%cf%81%cf%8c%ce%bb%ce%bf%cf%82-%cf%84%ce%bf%cf%85","status":"publish","type":"post","link":"https:\/\/armonia-zoi.gr\/%ce%bf-%ce%b1%ce%be%ce%bf%ce%bd%ce%b1%cf%82-%cf%84%cf%89%ce%bd-%ce%b9%ce%bd%ce%ba%cf%81%ce%b5%cf%84%ce%b9%ce%bd%cf%8e%ce%bd-%ce%ba%ce%b1%ce%b9-%ce%bf-%cf%81%cf%8c%ce%bb%ce%bf%cf%82-%cf%84%ce%bf%cf%85\/","title":{"rendered":"\u039f \u03b1\u03be\u03bf\u03bd\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 2"},"content":{"rendered":"<p><b><i>\u0393\u03c1\u03b7\u03b3\u03cc\u03c1\u03b9\u03bf\u03c2 \u03a1\u03bf\u03bc\u03c0\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2 \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<\/i><\/b><\/p>\n<p><b><\/p>\n<p>\u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7<\/b><\/p>\n<p>\u0397 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd, \u03c4\u03c9\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf, \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c4\u03bf GLP-1 (glucagon like peptide-1) \u03ba\u03b1\u03b9 \u03c4\u03bf GIP (glucose- dependent- insulinotropic- polypeptide)\u00a0 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\u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03a3\u03942 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 GLP-1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b4\u03b9\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03cd\u03bb-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03ac\u03c3\u03b7-4 (DPP-4), \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03be\u03bf\u03c5\u03b4\u03b5\u03c4\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 GLP-1. \u0397 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 DPP-4 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 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\u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c8\u03b5\u03b9 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bb\u03b5\u03c0\u03c4\u03cc \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf \u03ba\u03b1\u03b9 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03ae \u03bc\u03bf\u03af\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2. \u03a4\u03bf 1964 \u03bf\u03b9 Mc Intyre \u03ba\u03b1\u03b9 Elrick \u03b4\u03c5\u03bf \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf incretin effect \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf: \u00ab\u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2 \u03c0\u03c1\u03bf\u03ba\u03ac\u03bb\u03b5\u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03b5\u03b2\u03af\u03c9\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u00bb. \u03a4\u03bf 1973 \u03ad\u03b3\u03b9\u03bd\u03b5 \u03b7 \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03b7\u03c2 GIP \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bf\u03bd\u03bf\u03bc\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac gastric inhibitory peptide \u03b4\u03b9\u03cc\u03c4\u03b9 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03bd \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03c3\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u0391\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5\u03c4\u03bf\u03bd\u03bf\u03bc\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5 \u03c3\u03b5 glucose- dependent- insulinotropic- polypeptide\u00a0 \u03b4\u03b9\u03cc\u03c4\u03b9 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03b5\u03af\u03c7\u03b5 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b3\u03bb\u03c5\u03ba\u03bf\u03b6\u03bf\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03ad\u03ba\u03ba\u03bb\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03ac\u03b3\u03ba\u03c1\u03b5\u03b1\u03c2. \u03a4\u03bf 1986 \u03bf Nauck Michael \u03b1\u03c0\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03c4\u03bf incretin effect \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2 (\u03a3\u03942) \u03b5\u03bd\u03ce \u03c4\u03bf 1987 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 2<sup>\u03b7\u03c2<\/sup> \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 GLP-1 (glucagon like peptide-1) \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2. \u03a0\u03ae\u03c1\u03b5 \u03c4\u03bf \u03cc\u03bd\u03bf\u03bc\u03b1 \u03b1\u03c5\u03c4\u03cc \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c7\u03b7\u03bc\u03b9\u03ba\u03ae\u03c2 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7. \u03a4\u03bf 1995 \u03b1\u03bd\u03b1\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03cd\u03bb-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03ac\u03c3\u03b7 4 (DPP-4) \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd GIP \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd GLP-1 \u03bb\u03af\u03b3\u03b1 \u03bc\u03cc\u03bb\u03b9\u03c2 \u03bb\u03b5\u03c0\u03c4\u03ac \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1.<\/p>\n<p>\u039f\u03b9 \u03b1\u03bd\u03b1\u03ba\u03b1\u03bb\u03cd\u03c8\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b1\u03bd \u03c3\u03b5 \u03c3\u03ba\u03ad\u03c8\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03a3\u03942 (\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 DPP4, incretin mimetics )\u03b1\u03c6\u03bf\u03cd \u03ae\u03c4\u03b1\u03bd \u03b5\u03af\u03b4\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03b7 \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf \u03a3\u03942.<\/p>\n<p><b><br \/>\n\u039f\u03b9 \u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b4\u03b9\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03c5\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03ac\u03c3\u03b7\u03c2-4<\/b><\/p>\n<p>\u039f\u03b9 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03af\u03bd\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c1\u03bc\u03cc\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bb\u03b5\u03c0\u03c4\u03cc \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03c4\u03c1\u03bf\u03c6\u03ae\u03c2, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c5\u03b4\u03b1\u03c4\u03b1\u03bd\u03b8\u03c1\u03ac\u03ba\u03c9\u03bd. 1,2 \u039c\u03b5\u03c4\u03b1\u03be\u03cd \u03ac\u03bb\u03bb\u03c9\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ce\u03bd, \u03bf\u03b9 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03af\u03bd\u03b5\u03c2 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7\u03c2. 2 \u038c\u03c4\u03b1\u03bd \u03b5\u03ba\u03ba\u03c1\u03b9\u03b8\u03bf\u03cd\u03bd \u03bf\u03b9 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03af\u03bd\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03c3\u03ba\u03ae\u03c3\u03bf\u03c5\u03bd \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b5\u03c0\u03b9\u03b2\u03c1\u03ac\u03b4\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03ba\u03ad\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ce\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd. \u0396\u03c9\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03af\u03bd\u03b5\u03c2 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03b2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.3<\/p>\n<p>\u0397 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03c0\u03bf\u03bb\u03c5\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc<\/p>\n<p>\u03c4\u03bf \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf \u03c4\u03bf GLP-1 \u03ba\u03b1\u03b9 \u03c4\u03bf GIP. \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b4\u03cd\u03bf \u03c0\u03bf\u03bb\u03c5\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03c9\u03b8\u03b5\u03af \u03c0\u03c9\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ba\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 (incretin effect) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03ac\u03b3\u03ba\u03c1\u03b5\u03b1\u03c2 \u03c3\u03b1\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c4\u03c1\u03bf\u03c6\u03ae. 3,4<\/p>\n<p>\u03a4\u03bf GLP-1 \u03c3\u03c5\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03ac L-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 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3<\/p>\n<p>\u03a4\u03bf GIP \u03c3\u03c5\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u039a \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03b3\u03b3\u03cd\u03c2 \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03bf \u039d \u03ac\u03ba\u03c1\u03bf \u03c4\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03bf \u03bc\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf\u03c5 GLP-1 \u03c3\u03c4\u03bf \u03cc\u03c4\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 GIP \u03c3\u03c4\u03b1 \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1 \u03ba\u03b1\u03b9 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\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b5\u03bb\u03ac\u03c4\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03b2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2.<\/p>\n<p><b><br \/>\n\u039f\u03b9 \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03af\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03c5\u03bb\u03b9\u03ba\u03ae \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03ac\u03c3\u03b7-4<\/b><\/p>\n<p>\u0397 \u03b4\u03b9\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03c5\u03bb\u03b9\u03ba\u03ae \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03ac\u03c3\u03b7-4 (DPP-4) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03b5\u03c1\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ad\u03bc\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03c3\u03b5 \u03cc\u03bb\u03bf \u03c4\u03bf \u03c3\u03ce\u03bc\u03b1. \u03a4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03b4\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03be\u03bf\u03c5\u03b4\u03b5\u03c4\u03b5\u03c1\u03ce\u03c3\u03b5\u03b9 \u03bf\u03bb\u03b9\u03b3\u03bf\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03b4\u03b9\u03b1\u03c3\u03c0\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b4\u03cd\u03bf \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u039d \u03ac\u03ba\u03c1\u03bf. \u03a4\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 DPP-4 \u03c3\u03c4\u03bf \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf GLP-1 \u03ba\u03b1\u03b9 \u03c4\u03bf GIP. \u03a9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf DPP-4, &gt;50% \u03c4\u03bf\u03c5 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd\u03c4\u03bf\u03c2 GLP-1 \u03b5\u03be\u03bf\u03c5\u03b4\u03b5\u03c4\u03b5\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 1-2 \u03bb\u03b5\u03c0\u03c4\u03ac \u03b5\u03bd\u03ce \u03bf \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b7\u03bc\u03af\u03c3\u03b5\u03b9\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03c4\u03bf\u03c5 GIP \u03b5\u03af\u03bd\u03b1\u03b9 ~7 \u03bb\u03b5\u03c0\u03c4\u03ac.22 \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf GLP-1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf GIP \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c0\u03b1\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2.<\/p>\n<p><b><\/p>\n<p>\u0397 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 DPP<\/b><b>-4 \u03ba\u03b1\u03b9 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 GLP<\/b><b>-1 \u03b1\u03bd\u03b1\u03bb\u03cc\u03b3\u03c9\u03bd \u03c9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03a3\u03942<\/b><br \/>\n\u039c\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ac\u03be\u03bf\u03bd\u03b1 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd \u03c3\u03c4\u03bf \u03a3\u03942 \u03b5\u03af\u03b4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 80 \u03c5\u03c0\u03ae\u03c1\u03c7\u03b1\u03bd \u03bf\u03b9 \u03c3\u03ba\u03ad\u03c8\u03b5\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 GLP-1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c3\u03b1\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u03a4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03bc\u03b5 \u03c4\u03bf GLP-1 \u03ae\u03c4\u03b1\u03bd \u03cc\u03c4\u03b9 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc\u03c3\u03c5\u03c1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03b8\u03b1 \u03ad\u03c0\u03c1\u03b5\u03c0\u03b5 \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03ba\u03ac\u03b8\u03b5 \u03b3\u03b5\u03cd\u03bc\u03b1 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03b1 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03bf\u03c1\u03c6\u03ae\u03c2. \u0391\u03c5\u03c4\u03cc \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03c4\u03b7\u03bd \u03c3\u03ba\u03ad\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03bd\u03b1\u03bb\u03cc\u03b3\u03bf\u03c5 GLP-1 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03bd\u03b1 \u03bc\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd DPP4 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b1\u03bd\u03b1\u03b3\u03ba\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03b3\u03b5\u03cd\u03bc\u03b1, \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b8\u03b1 \u03b4\u03b9\u03ad\u03c6\u03b5\u03c1\u03b5 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2. \u0391\u03c5\u03c4\u03cc \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03af\u03b4\u03b7 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03be\u03b5\u03bd\u03b1\u03c4\u03af\u03b4\u03b7, \u03ad\u03bd\u03b1 \u03b5\u03bd\u03ad\u03c3\u03b7\u03bc\u03bf \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03bf \u03c4\u03b7\u03c2 GLP-1.<\/p>\n<p>\u039f \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 DPP-4 \u03c3\u03c4\u03b7\u03bd \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b5\u03be\u03bf\u03c5\u03b4\u03b5\u03c4\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 GLP-1 \u03b4\u03b7\u03bc\u03b9\u03bf\u03cd\u03c1\u03b3\u03b7\u03c3\u03b5 \u03c4\u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c8\u03b5\u03b9 \u03c3\u03c4\u03bf GLP-1 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03bf\u03c5\u03b4\u03b5\u03c4\u03ad\u03c1\u03c9\u03c3\u03b7. \u03a3\u03c4\u03bf\u03bd \u03a3\u03942 \u03b7 \u03b5\u03bb\u03b1\u03c4\u03c4\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd \u03c3\u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bc\u03b9\u03b1 \u03b1\u03bd\u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2\/\u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7\u03c2, \u03bc\u03b5 \u03b5\u03bb\u03ac\u03c4\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7\u03c2 \u03b5\u03be\u03b1\u03b9\u03c4\u03af\u03b1\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b1 \u03ba\u03b1\u03b9 \u03b2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0391\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd DPP-4, \u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b1\u03b8\u03b5\u03af, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03ce\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd.22 \u03a9\u03c2<\/p>\n<p>\u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1, \u03b7 \u03b1\u03bd\u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2\/\u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03bf\u03c1\u03b8\u03c9\u03b8\u03b5\u03af \u03ce\u03c3\u03c4\u03b5 \u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b2 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b1 \u03b1\u03c5\u03be\u03b7\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b3\u03cc\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03b5\u03af. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bd\u03b7\u03c3\u03b9\u03b4\u03af\u03c9\u03bd \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf. \u0391\u03c5\u03c4\u03ae \u03ae\u03c4\u03b1\u03bd \u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03c9\u03bd DPP4 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b5\u03af\u03b4\u03b7 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03ba\u03c5\u03ba\u03be\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03b4\u03cd\u03bf \u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 DPP-4 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd \u03b7 \u03b2\u03b9\u03bb\u03bd\u03c4\u03b1\u03b3\u03bb\u03b9\u03c0\u03c4\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03b9\u03c4\u03b1\u03b3\u03bb\u03b9\u03c0\u03c4\u03af\u03bd\u03b7. \u039f\u03b9 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03bf\u03af \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 DPP-4. \u039c\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 DPP-4 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b1 \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1 \u03ba\u03b1\u03b9 \u03b2 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03a3\u03942 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03b9\u03ba\u03bf\u03c5 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c5.<\/p>\n<p>\u03a3\u03b5 \u03b6\u03c9\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1, \u03b7 \u03b2\u03b9\u03bb\u03bd\u03c4\u03b1\u03b3\u03bb\u03b9\u03c0\u03c4\u03af\u03bd\u03b7 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03a3\u03942 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03ac\u03b6\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7.<\/p>\n<p>\u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2, \u03ad\u03bd\u03b1 \u03b5\u03c0\u03b9\u03b8\u03c5\u03bc\u03b7\u03c4\u03cc \u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03ac\u03b6\u03b1 \u03c4\u03c9\u03bd \u03b2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u03a3\u03b5 \u03bc\u03af\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03c9\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 48 \u03c9\u03c1\u03ce\u03bd \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03ad\u03ba\u03b4\u03bf\u03c7\u03b1 (\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf) \u03ae \u03b2\u03b9\u03bb\u03bd\u03c4\u03b1\u03b3\u03bb\u03b9\u03c0\u03c4\u03af\u03bd\u03b7 (60 mg\/kg \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1),16 \u03b7 \u03b2\u03b9\u03bb\u03bd\u03c4\u03b1\u03b3\u03bb\u03b9\u03c0\u03c4\u03af\u03bd\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03bc\u03ac\u03b6\u03b1 \u03c4\u03c9\u03bd \u03b2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7. \u0397 \u03af\u03b4\u03b9\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf \u03c0\u03b1\u03c1\u03cc\u03bd \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2.<\/p>\n<p>&nbsp;<\/p>\n<p>\u039f\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2 \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7\u03c2 GLP-1 mimetic \u03b5\u03be\u03b5\u03bd\u03b1\u03c4\u03af\u03b4\u03b7\u03c2,\u00a0 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd DPP-4 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd \u03b2\u03b9\u03bb\u03bd\u03c4\u03b1\u03b3\u03bb\u03b9\u03c0\u03c4\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b9\u03c4\u03b1\u03b3\u03bb\u03b9\u03c0\u03c4\u03af\u03bd\u03b7\u03c2, \u03bc\u03b1\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03ae\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c3\u03c4\u03b7\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 HbA1c \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c0\u03bb\u03b5\u03bf\u03bd\u03b5\u03ba\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b7\u03bd \u03bc\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03ae \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03b5 \u03ba\u03ac\u03c0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 (\u03b5\u03be\u03b5\u03bd\u03b1\u03c4\u03af\u03b4\u03b7) \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c5\u03c0\u03bf\u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03c9\u03bd. \u0395\u03bd\u03ce \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03ba\u03ac\u03c0\u03bf\u03b9\u03b5\u03c2 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03bf\u03c7\u03bb\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03be\u03b5\u03bd\u03b1\u03c4\u03af\u03b4\u03b7.<br \/>\n<b>\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/b><\/p>\n<p>&nbsp;<\/p>\n<ol start=\"1\">\n<li>Creutzfeldt W. The incretin concept today. Diabetologia 1979; 16: 75-85.<\/li>\n<li>Holst JJ. Therapy of type 2 diabetes mellitus based on the actions of glucagonlike peptide-1. Diabetes Metab Res Rev 2002; 18: 430-441.<\/li>\n<li>Drucker DJ. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 2003; 26: 2929-2940.<\/li>\n<li>Vilsb\u00f8ll T, Holst JJ. Incretins, insulin secretion and type 2 diabetes mellitus. Diabetologia 2004; 47: 357-366.<\/li>\n<li>Mojsov S, Heinrich G, Wilson IB, et al. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 1986; 261: 11880-11889.<\/li>\n<li>Nauck MA, Homberger E, Siegel EG, et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 1986; 63: 492-498.<\/li>\n<li>Ahr\u00e9n B. Inhibition of dipeptidyl peptidase-4 (DPP-4) \u2013 a novel approach to treat type 2 diabetes. Curr Enzyme Inhib 2005; 1: 65-73.<\/li>\n<li>Unger RH. Alpha- and beta-cell interrelationships in health and disease. Metabolism 1974; 23: 581-593.<\/li>\n<li>Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagonlike peptide 1 on glycaemic control, insulin sensitivity, and b-cell function in type 2 diabetes: a parallel-group study. Lancet 2002; 359: 824-830.<\/li>\n<li>Nauck MA, Kleine N, \u00d8rskov C, et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulindependent) diabetic patients. Diabetologia 1993; 36: 741-744.<\/li>\n<li>Young AA, Gedulin BR, Bhavsar S, et al. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob\/ob, db\/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 1999; 48:1026-1034.<\/li>\n<li>Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both b-cell replication and neogenesis, resulting in increased b-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999; 48: 2270-2276.<\/li>\n<li>Stoffers DA, Kieffer TJ, Hussain MA, et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000; 49: 741-748.<\/li>\n<li>Abraham EJ, LeechCA, Lin JC, et al. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology 2002; 143: 3152-3161.<\/li>\n<li>Farilla L, Hui H, Bertolotto C, et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 2002; 143:4397-4408.<\/li>\n<li>Duttaroy A, Voelker F, Merriam K, et al. The DPP-4 inhibitor vildagliptin increases pancreatic beta-cell neogenesis and decreases apoptosis. ADA Annual Meeting 2005; 572-P (abstract).<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u0393\u03c1\u03b7\u03b3\u03cc\u03c1\u03b9\u03bf\u03c2 \u03a1\u03bf\u03bc\u03c0\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2 \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u0397 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b9\u03bd\u03ba\u03c1\u03b5\u03c4\u03b9\u03bd\u03ce\u03bd, \u03c4\u03c9\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf, \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c4\u03bf GLP-1 (glucagon like peptide-1) \u03ba\u03b1\u03b9 \u03c4\u03bf GIP (glucose- dependent- insulinotropic- polypeptide)\u00a0 \u03c0\u03b1\u03af\u03b6\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2&hellip;<\/p>\n<p class=\"more-link-p\"><a class=\"more-link\" href=\"https:\/\/armonia-zoi.gr\/%ce%bf-%ce%b1%ce%be%ce%bf%ce%bd%ce%b1%cf%82-%cf%84%cf%89%ce%bd-%ce%b9%ce%bd%ce%ba%cf%81%ce%b5%cf%84%ce%b9%ce%bd%cf%8e%ce%bd-%ce%ba%ce%b1%ce%b9-%ce%bf-%cf%81%cf%8c%ce%bb%ce%bf%cf%82-%cf%84%ce%bf%cf%85\/\">Read more &rarr;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_newsletter_tier_id":0,"footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[10,11],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4lxm8-6s","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/posts\/400"}],"collection":[{"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/comments?post=400"}],"version-history":[{"count":1,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/posts\/400\/revisions"}],"predecessor-version":[{"id":401,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/posts\/400\/revisions\/401"}],"wp:attachment":[{"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/media?parent=400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/categories?post=400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/armonia-zoi.gr\/wp-json\/wp\/v2\/tags?post=400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}